Treatment of severe sepsis with nanoparticulate cell-free DNA scavengers

Author:

Dawulieti Jianati1ORCID,Sun Madi12,Zhao Yawei1,Shao Dan23ORCID,Yan Huize3,Lao Yeh-Hsing3,Hu Hanze3,Cui Lianzhi4,Lv Xiaoyan5,Liu Feng36,Chi Chun-Wei7,Zhang Yue1,Li Mingqiang38ORCID,Zhang Ming1,Tian Huayu6,Chen Xuesi6,Leong Kam W.39ORCID,Chen Li1ORCID

Affiliation:

1. Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences and School of Nursing, Jilin University, Changchun 130021, China.

2. Institutes of Life Sciences, National Engineering Research Center for Tissue Restoration and Reconstruction, School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong 510006, China.

3. Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

4. Clinical Laboratory, Jilin Cancer Hospital, Changchun 130012, China.

5. Clinical Laboratory, The Second Hospital of Jilin University, Changchun 130021, China.

6. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.

7. Department of Biomedical Engineering CUNY–City College of New York, New York, NY 10031, USA.

8. Guangdong Provincial Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.

9. Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA.

Abstract

Cationic nanoparticles ameliorate severe sepsis progression through scavenging cell-free DNA.

Funder

National Institutes of Health

National Natural Science Foundation of China

Science and technology development projects of Jilin Province

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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