Nanoparticle interactions with immune cells dominate tumor retention and induce T cell–mediated tumor suppression in models of breast cancer-Reference-Cited by-同舟云学术

Nanoparticle interactions with immune cells dominate tumor retention and induce T cell–mediated tumor suppression in models of breast cancer

Published:2020-03-27 Issue:13 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Korangath Preethi¹^ORCID,Barnett James D.¹^ORCID,Sharma Anirudh¹,Henderson Elizabeth T.¹^ORCID,Stewart Jacqueline¹,Yu Shu-Han¹,Kandala Sri Kamal¹²^ORCID,Yang Chun-Ting¹³^ORCID,Caserto Julia S.¹^ORCID,Hedayati Mohammad¹,Armstrong Todd D.⁴,Jaffee Elizabeth⁴^ORCID,Gruettner Cordula⁵,Zhou Xian C.⁶,Fu Wei⁶^ORCID,Hu Chen⁶^ORCID,Sukumar Saraswati⁴^ORCID,Simons Brian W.⁷^ORCID,Ivkov Robert¹²⁴⁸⁹^ORCID

Affiliation:

1. Department of Radiation Oncology and Molecular Radiation Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.

2. Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore 21218, USA.

3. National Taiwan University, Taipei 10617, Taiwan.

4. Department of Oncology, Sidney Kimmel Comprehensive Cancer Centre, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.

5. micromod Partikeltechnologie GmbH, Rostock, Germany.

6. Department of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Centre, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.

7. Department of Urology, James Buchanan Brady Urological Institute, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.

8. Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore 21218, USA.

9. Institute for NanoBioTechnology, Whiting School of Engineering, Johns Hopkins University, Baltimore 21218, USA.

Abstract

Systemic exposure to nanoparticles induces immune responses that lead to anticancer immune activation.

Funder

National Institutes of Health

National Cancer Institute

Jayne Koskinas Ted Giovanis Foundation for Health and Policy

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

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