Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders

Author:

Lin Huirong1ORCID,Zhou Yu1,Wang Jiaming2ORCID,Wang Huimeng1,Yao Tianhong1ORCID,Chen Hu1ORCID,Zheng Huili1,Zhang Yang1ORCID,Ren En1ORCID,Jiang Lai1,Chu Chengchao13ORCID,Chen Xiaoyuan4ORCID,Mao Jingsong15ORCID,Wang Fudi26ORCID,Liu Gang1ORCID

Affiliation:

1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.

2. The Fourth Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.

3. Amoy Hopeful Biotechnology Co. Ltd., Xiamen 361027, China.

4. Departments of Diagnostic Radiology, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, Singapore.

5. Department of Radiology, Xiang’an Hospital of Xiamen University, Xiamen 361102, China.

6. The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.

Abstract

Indocyanine green was repurposed as iron theranostics for simultaneous detection and treatment of iron-overload disorders.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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