Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma-Reference-Cited by-同舟云学术

Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma

Published:2021-02-19 Issue:8 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Miska Jason¹^ORCID,Rashidi Aida¹^ORCID,Lee-Chang Catalina¹,Gao Peng²^ORCID,Lopez-Rosas Aurora¹,Zhang Peng¹,Burga Rachel¹,Castro Brandyn¹^ORCID,Xiao Ting¹^ORCID,Han Yu¹^ORCID,Hou David¹,Sampat Samay¹,Cordero Alex¹^ORCID,Stoolman Joshua S.³^ORCID,Horbinski Craig M.¹^ORCID,Burns Mark⁴^ORCID,Reshetnyak Yana K.⁵,Chandel Navdeep S.³^ORCID,Lesniak Maciej S.¹^ORCID

Affiliation:

1. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.

2. Metabolomics Core Facility, Feinberg School of Medicine, Northwestern University, 710 N Fairbanks Court, Chicago, IL 60611, USA.

3. Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2330, Chicago, IL 60611, USA.

4. Aminex Therapeutics Inc., Epsom, NH 03234, USA.

5. Physics Department, University of Rhode Island, Kingston, RI 02881, USA.

Abstract

Glioma-associated myeloid cells generate polyamines to survive and function within the acidic tumor microenvironment.

Funder

National Cancer Institute

National Institute of Neurological Disorders and Stroke

Publisher

American Association for the Advancement of Science (AAAS)

Subject