Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles-Reference-Cited by-同舟云学术

Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles

Published:2021-04-30 Issue:18 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Guo Yutong¹^ORCID,Lee Hohyun¹^ORCID,Fang Zhou²,Velalopoulou Anastasia¹,Kim Jinhwan¹^ORCID,Thomas Midhun Ben³,Liu Jingbo⁴^ORCID,Abramowitz Ryan G.¹,Kim YongTae¹²^ORCID,Coskun Ahmet F.²^ORCID,Krummel Daniel Pomeranz⁵,Sengupta Soma⁵^ORCID,MacDonald Tobey J.⁴,Arvanitis Costas¹²^ORCID

Affiliation:

1. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

2. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.

3. Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.

4. Department of Pediatrics, Aflac Cancer and Blood, Emory University School of Medicine, Atlanta, GA, USA.

5. Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Abstract

Focused ultrasound–mediated delivery of RNA-loaded nanoparticles increases brain tumor cell apoptosis through oncogene targeting.

Funder

National Cancer Institute

National Institute of Biomedical Imaging and Bioengineering

National Cancer Institute, Cairo University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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