Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8 + T cell response in tumor-Reference-Cited by-同舟云学术

Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8 + T cell response in tumor

Published:2020-05-29 Issue:22 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wang Yuan¹^ORCID,Wang Xinting¹^ORCID,Cui Xiaoteng¹^ORCID,Zhuo Yue²,Li Hongshuai¹,Ha Chuanbo¹^ORCID,Xin Lingbiao¹^ORCID,Ren Yuanyuan¹,Zhang Wei¹,Sun Xiaoming¹,Ge Lin¹,Liu Xin¹,He Jinyan¹,Zhang Tao²,Zhang Kai¹^ORCID,Yao Zhi¹^ORCID,Yang Xi³^ORCID,Yang Jie¹^ORCID

Affiliation:

1. Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Key Laboratory of Cellular and Molecular Immunology, Excellent Talent Project, Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

2. School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.

3. Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.

Abstract

Oncoprotein SND1 induces ER-associated degradation for nascent MHC-I heavy chain, leading to impaired CD8 + T cell response in tumor.

Funder

National Natural Science Foundation of China

National Science Foundation for Distinguished Young Scholars of China

Innovation Team Development Plan of the Ministry of Education

Postgraduate Innovation Fund of ‘13th Five-Year comprehensive investment

High-level Innovation and Entrepreneurship Team of Tianjin Talent Development Special Support Plan

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Rejection versus escape: the tumor MHC dilemma

2. Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells

3. The urgent need to recover MHC class I in cancers for effective immunotherapy

4. HLA class I antigen abnormalities and immune escape by malignant cells

5. Analysis of HLA expression in human tumor tissues

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