Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration

Author:

Zhu Yizhou123ORCID,Liang Hang4ORCID,Liu Xiangmei2ORCID,Wu Jun3,Yang Cao4ORCID,Wong Tak Man13,Kwan Kenny Y. H.13ORCID,Cheung Kenneth M. C.13,Wu Shuilin5ORCID,Yeung Kelvin W. K.136ORCID

Affiliation:

1. Department of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong 999077, China.

2. School of Materials Science & Engineering, Hubei University, Wuhan 430062, China.

3. Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, Department of Orthopaedics and Traumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China.

4. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

5. School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

6. China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China.

Abstract

Scale-dependent osteo-immune regulation induced by specific TiO 2 nanostructure accelerates implant-to-bone integration.

Funder

National Key Research and Development Program of China Stem Cell and Translational Research

Hong Kong Health and Medical Research Fund

General Research Fund of Hong Kong Research Grant Council

Shenzhen Science and Technology Funding

National Science Fund for distinguished Youth Scholar

HKU-SZH Fund for Shenzhen Key Medical Discipline

Sanming Project of Medicine in Shenzhen “Team of Excellence in Spinal Deformities and Spinal Degeneration”

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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