Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes-Reference-Cited by-同舟云学术

Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes

Published:2020-08-21 Issue:34 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Warre-Cornish Katherine¹²^ORCID,Perfect Leo¹²^ORCID,Nagy Roland¹²^ORCID,Duarte Rodrigo R. R.³⁴,Reid Matthew J.¹²^ORCID,Raval Pooja¹²,Mueller Annett⁵,Evans Amanda L.⁵,Couch Amalie¹²^ORCID,Ghevaert Cédric⁵,McAlonan Grainne²⁶^ORCID,Loth Eva²⁶^ORCID,Murphy Declan²⁶^ORCID,Powell Timothy R.³⁴,Vernon Anthony C.¹²^ORCID,Srivastava Deepak P.¹²^ORCID,Price Jack¹²⁷^ORCID

Affiliation:

1. Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.

2. MRC Centre for Neurodevelopmental Disorders, King’s College London, London, UK.

3. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.

4. Division of Infectious Diseases, Weill Cornell Medicine, Cornell University, New York, NY, USA.

5. Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.

6. Department of Forensic and Neurodevelopmental Sciences, King’s College London, London, UK.

7. National Institute for Biological Standards and Control, South Mimms, UK.

Abstract

Interferon-γ induces cellular and transcriptomic changes in human neural cells associated with neurodevelopmental disorders.

Funder

Brain and Behavior Research Foundation

Seventh Framework Programme

Innovative Medicines Initiative

wellcome trust issf grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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