RUNX represses Pmp22 to drive neurofibromagenesis

Author:

Hall Ashley1ORCID,Choi Kwangmin1ORCID,Liu Wei1,Rose Jonathan1,Zhao Chuntao1,Yu Yanan12,Na Youjin1,Cai Yuqi1,Coover Robert A.1,Lin Yi1,Dombi Eva3,Kim MiOk4ORCID,Levanon Ditsa5ORCID,Groner Yoram5,Boscolo Elisa16,Pan Dao16ORCID,Liu P. Paul7,Lu Q. Richard16,Ratner Nancy16,Huang Gang16,Wu Jianqiang16ORCID

Affiliation:

1. Cincinnati Children’s Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

2. Department of Cancer and Cell Biology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.

3. Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.

4. Department of Epidemiology and Biostatistics, UCSF, Box 0128, 1450 3rd St. Suite 285, San Francisco, CA 94143, USA.

5. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

6. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

7. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

RUNX 1 and RUNX3 drive Nf1 neurofibromagenesis by mediating the promoter usage and inducing levels of protein expression of PMP22.

Funder

National Institute of Neurological Disorders and Stroke

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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