Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype

Author:

Qu Changxiu12ORCID,Mao Chunyou34,Xiao Peng2,Shen Qingya34ORCID,Zhong Ya-Ni2,Yang Fan2,Shen Dan-Dan34ORCID,Tao Xiaona2,Zhang Huibing34ORCID,Yan Xu25,Zhao Ru-Jia2,He Junyan2,Guan Ying2,Zhang Chao6,Hou Guihua6,Zhang Peng-Ju2,Hou Guige7ORCID,Li Zijian8,Yu Xiao5,Chai Ren-Jie9ORCID,Guan You-Fei10,Sun Jin-Peng12ORCID,Zhang Yan341112ORCID

Affiliation:

1. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China.

2. Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo college of Medicine, Shandong University, Jinan, Shandong 250012, China.

3. Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.

4. Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou 311121, China.

5. Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

6. Biomedical Isotope Research Center, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

7. School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, China.

8. Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Research, Beijing 100191, China.

9. State Key Laboratory of Bioelectronics, Co-Innovation Center of Neuroregeneration, School of Life Sciences and Technology, Southeast University, Nanjing 210096, China.

10. Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.

11. MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou 310058, China.

12. Zhejiang Provincial Key Laboratory of Immunity and Inflammatory Diseases, Hangzhou 310058, China.

Abstract

Structures of prostaglandin receptor EP2 revealed its agonists’ selectivity and G protein coupling mechanism.

Funder

Key Technology Research and Development Program of Shandong

Fundamental Research Fund of Shandong University

National Natural Science Foundation of China

National Science Fund for Excellent Young Scholar

Shandong University Youth Interdisciplinary Science Innovation Group

Zhejiang Provincial Outstanding Youth Science Foundation

National Basic Research Program of China

National Science Fund for Distinguished Young Scholars

China Postdoctoral Science Foundation

Natural Science Foundation of Shandong Province

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3