Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity-Reference-Cited by-同舟云学术

Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity

Published:2019-08-02 Issue:8 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Taylor Michael R.¹²³^ORCID,Flannigan Kyle L.⁴⁵,Rahim Hannah¹²³^ORCID,Mohamud Amina¹²³^ORCID,Lewis Ian A.⁶^ORCID,Hirota Simon A.⁴⁵⁷^ORCID,Greenway Steven C.¹²³⁸^ORCID

Affiliation:

1. Departments of Pediatrics and Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

2. Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

3. Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

4. Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

5. Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

6. Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.

7. Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

8. Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Abstract

Toxicity from the immunosuppressant mycophenolate mofetil is prevented by eliminating gut bacteria expressing β-glucuronidase.

Funder

Canadian National Transplant Research Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. Pharmacology and toxicology of mycophenolate in organ transplant recipients: an update

2. Review of major clinical trials with mycophenolate mofetil in cardiac transplantation;Kobashigawa J. A.;Transplantation,2005

3. Drug-induced injury in the gastrointestinal tract;Panarelli N. C.;Semin. Diagn. Pathol.,2014

4. Endoscopic and histological features of mycophenolate mofetil colitis in patients after solid organ transplantation;Calmet F. H.;Ann. Gastroenterol.,2015

5. Mycophenolate mofetil dose reduction and the risk of acute rejection after renal transplantation;Knoll G. A.;J. Am. Soc. Nephrol.,2003

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