New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration

Author:

Kaneko N.1ORCID,Herranz-Pérez V.23ORCID,Otsuka T.45,Sano H.56,Ohno N.78ORCID,Omata T.1,Nguyen H. B.89,Thai T. Q.8ORCID,Nambu A.56ORCID,Kawaguchi Y.45ORCID,García-Verdugo J. M.2ORCID,Sawamoto K.110ORCID

Affiliation:

1. Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.

2. Laboratory of Comparative Neurobiology, Instituto Cavanilles, Universidad de Valencia, CIBERNED, C/Catedrático José Beltrán, 2, Paterna, 46980 Valencia, Spain.

3. Predepartamental Unit of Medicine, Faculty of Health Sciences, Universitat Jaume I, Q-6250003-H Av. de Vicent Sos Baynat, s/n, 12071 Castelló de la Plana, Spain.

4. Division of Cerebral Circuitry, National Institute for Physiological Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.

5. Department of Physiological Sciences, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi 444-8585, Japan.

6. Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan.

7. Department of Anatomy, Division of Histology and Cell Biology, Jichi Medical University, School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

8. Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.

9. Department of Anatomy, Faculty of Medicine, University of Medicine and Pharmacy (UMP), Ho Chi Minh City 700000, Vietnam.

10. Division of Neural Development and Regeneration, National Institute for Physiological Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.

Abstract

Appropriate positioning of new neurons in the brain promotes post-stroke functional recovery.

Funder

Takeda Science Foundation

Brain Science Foundation

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science, and Technology

Nagoya City University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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