Sprayable biomimetic double mask with rapid autophasing and hierarchical programming for scarless wound healing-Reference-Cited by-同舟云学术

Sprayable biomimetic double mask with rapid autophasing and hierarchical programming for scarless wound healing

Published:2024-08-16 Issue:33 Volume:10 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yang Yuhe¹^ORCID,Suo Di¹^ORCID,Xu Tianpeng¹^ORCID,Zhao Shuai¹,Xu Xiaoxiao¹²³^ORCID,Bei Ho-Pan¹²³,Wong Kenneth Kak-yuen⁴^ORCID,Li Qibin⁵⁶,Zheng Zijian¹⁷^ORCID,Li Bin⁸⁹^ORCID,Zhao Xin¹³⁵⁷¹⁰^ORCID

Affiliation:

1. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.

2. Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.

3. The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, Guangdong 518057, China.

4. Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

5. Research Center for Intelligent Aesthetic Medicine, PolyU-Hangzhou Technology and Innovation Research Institute, Hangzhou, Zhejiang 310016, China.

6. Hangzhou Industrial Investment Group Co., Ltd., Hangzhou, Zhejiang, 310025, China.

7. Research Institute for Intelligent Wearable Systems, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.

8. Medical 3D Printing Center, Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

9. Orthopedic Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.

10. Research Institute for Future Food, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.

Abstract

Current sprayable hydrogel masks lack the stepwise protection, cleansing, and nourishment of extensive wounds, leading to delayed healing with scarring. Here, we develop a sprayable biomimetic double wound mask (BDM) with rapid autophasing and hierarchical programming for scarless wound healing. The BDMs comprise hydrophobic poly (lactide- co –propylene glycol– co -lactide) dimethacrylate (PLD) as top layer and hydrophilic gelatin methacrylate (GelMA) hydrogel as bottom layer, enabling swift autophasing into bilayered structure. After photocrosslinking, BDMs rapidly solidify with strong interfacial bonding, robust tissue adhesion, and excellent joint adaptiveness. Upon implementation, the bottom GelMA layer could immediately release calcium ion for rapid hemostasis, while the top PLD layer could maintain a moist, breathable, and sterile environment. These traits synergistically suppress the inflammatory tumor necrosis factor–α pathway while coordinating the cyclic guanosine monophosphate/protein kinase G–Wnt/calcium ion signaling pathways to nourish angiogenesis. Collectively, our BDMs with self-regulated construction of bilayered structure could hierarchically program the healing progression with transformative potential for scarless wound healing.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciadv.ado9479

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