Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanics-Reference-Cited by-同舟云学术

Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanics

Published:2021-10-15 Issue:42 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Nyga Agata¹²^ORCID,Muñoz Jose J.³⁴⁵^ORCID,Dercksen Suze⁶,Fornabaio Giulia¹⁷,Uroz Marina¹⁸,Trepat Xavier¹⁹¹⁰¹¹^ORCID,Baum Buzz²¹²^ORCID,Matthews Helen K.¹²^ORCID,Conte Vito¹⁶¹³^ORCID

Affiliation:

1. Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

2. MRC Laboratory of Molecular Biology, Cambridge, UK.

3. Department of Mathematics, Polytechnic University of Catalonia (UPC), Barcelona, Spain.

4. Centre Internacional de Mètodes Numèrics en Enginyeria (CIMNE), Barcelona, Spain.

5. Institut de Matemàtiques de la UPC - BarcelonaTech (IMTECH), Barcelona, Spain.

6. Department of Biomedical Engineering, Eindhoven University of Technology (TU/e), Eindhoven, Netherlands.

7. Department of Physics, University of Barcelona (UB), Barcelona, Spain.

8. Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA, USA.

9. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain.

10. Department of Biomedicine, University of Barcelona (UB), Barcelona, Spain.

11. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

12. MRC Laboratory of Molecular Cell Biology, University College London (UCL), London, UK.

13. Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology (TU/e), Eindhoven, Netherlands.

Abstract

Uniform RAS activation in an epithelium induces a 2D-to-3D transformation through induction of mechanical instability.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference54 articles.

1. The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial Packing

2. Epithelial Cell Packing Induces Distinct Modes of Cell Extrusions

3. Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis

4. The forces and fates of extruding cells

5. Mechanics of Epithelial Tissue Homeostasis and Morphogenesis

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