Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson’s disease-linked DNAJC6 mutations-Reference-Cited by-同舟云学术

Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson’s disease-linked DNAJC6 mutations

Published:2021-02-19 Issue:8 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wulansari Noviana¹²³^ORCID,Darsono Wahyu Handoko Wibowo¹²³^ORCID,Woo Hye-Ji¹²³^ORCID,Chang Mi-Yoon¹²³,Kim Jinil¹²³^ORCID,Bae Eun-Jin⁴^ORCID,Sun Woong⁵^ORCID,Lee Ju-Hyun⁵^ORCID,Cho Il-Joo⁶⁷⁸⁹^ORCID,Shin Hyogeun⁶⁷,Lee Seung-Jae⁴^ORCID,Lee Sang-Hun¹²³^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seoul, Republic of Korea.

2. Hanyang Biomedical Research Institute, Hanyang University, Seoul, Republic of Korea.

3. Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Republic of Korea.

4. Department of Biomedical Sciences and Medicine, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

5. Department of Anatomy, Brain Korea 21 PLUS Program for Biomedical Science, Korea University College of Medicine, Seoul 02841, Republic of Korea.

6. Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.

7. Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Daejeon, Republic of Korea.

8. School of Electrical and Electronics Engineering, Yonsei University, Seoul 03722, Republic of Korea.

9. Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul 03722, Republic of Korea.

Abstract

Human DNAJC6 Parkinson’s disease model reveals disruption of WNT-LMX1A regulatory loop during mDA neuron development.

Funder

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference63 articles.

1. Parkinson disease

2. Role of auxilin in uncoating clathrin-coated vesicles

3. A Deleterious Mutation in DNAJC6 Encoding the Neuronal-Specific Clathrin-Uncoating Co-Chaperone Auxilin, Is Associated with Juvenile Parkinsonism

4. DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability

5. D NAJC 6 Mutations Associated With Early-Onset Parkinson's Disease

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