FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats-Reference-Cited by-同舟云学术

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

Published:2021-07-30 Issue:31 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Porro Antonio¹^ORCID,Mohiuddin Mohiuddin²^ORCID,Zurfluh Christina¹,Spegg Vincent³,Dai Jingqi⁴^ORCID,Iehl Florence⁴,Ropars Virginie⁴^ORCID,Collotta Giulio¹^ORCID,Fishwick Keri M.¹,Mozaffari Nour L.¹^ORCID,Guérois Raphaël⁴^ORCID,Jiricny Josef¹,Altmeyer Matthias³,Charbonnier Jean-Baptiste⁴^ORCID,Pearson Christopher E.²⁵^ORCID,Sartori Alessandro A.¹^ORCID

Affiliation:

1. Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.

2. Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.

3. Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.

4. Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.

5. Program of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Abstract

FAN1-MLH1 interaction governs the processing of DNA interstrand crosslinks and disease-associated repeats.

Funder

Horizon 2020 Framework Programme

H2020 European Research Council

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

Swiss National Science Foundation

French Infrastructure for Integrated Structural Biology

Canadian Institutes for Health Research

Marigold Foundation

Petroff Family Fund

Kazman Family Fund

Krebsforschung Schweiz

Fondation ARC pour la Recherche sur le Cancer

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair

2. A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

3. Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents

4. Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

5. Characterization of the Interactome of the Human MutL Homologues MLH1, PMS1, and PMS2

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