Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

Author:

Wang Jinqiang123ORCID,Yu Jicheng3,Zhang Yuqi3,Zhang Xudong12,Kahkoska Anna R.4ORCID,Chen Guojun12,Wang Zejun12ORCID,Sun Wujin15,Cai Lulu126ORCID,Chen Zhaowei3,Qian Chenggen7ORCID,Shen Qundong7ORCID,Khademhosseini Ali12589ORCID,Buse John B.4ORCID,Gu Zhen123510ORCID

Affiliation:

1. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.

2. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.

3. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA.

4. Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

5. Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA, USA.

6. Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People's Hospital, University of Electronic, Science and Technology of China, Chengdu 611731, China.

7. Department of Polymer Science and Engineering and Key Laboratory of High-Performance Polymer Materials and Technology of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

8. Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

9. Department of Radiology, University of California, Los Angeles, Los Angeles, CA, USA.

10. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.

Abstract

A glucose-responsive insulin-polymer complex for self-regulated insulin release has been verified in diabetic mice and minipigs.

Funder

JDRF

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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