Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves

Author:

Zhang Yi12ORCID,Mickle Aaron D.34ORCID,Gutruf Philipp25ORCID,McIlvried Lisa A.34ORCID,Guo Hexia2ORCID,Wu Yixin2ORCID,Golden Judith P.34,Xue Yeguang67ORCID,Grajales-Reyes Jose G.34ORCID,Wang Xueju8ORCID,Krishnan Siddharth2ORCID,Xie Yiwen2ORCID,Peng Dongsheng29,Su Chun-Ju2,Zhang Fengyi10ORCID,Reeder Jonathan T.2ORCID,Vogt Sherri K.34,Huang Yonggang267ORCID,Rogers John A.211121314ORCID,Gereau Robert W.3415ORCID

Affiliation:

1. Department of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211, USA.

2. Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

3. Washington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.

4. Washington University School of Medicine, 660 S. Euclid Ave., Box 8054, St. Louis, MO 63110, USA.

5. Biomedical Engineering, College of Engineering, The University of Arizona, Bioscience Research Laboratories, 1230 N. Cherry Ave., Tucson, AZ 85721, USA.

6. Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

7. Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

8. Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA.

9. College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

10. School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30318, USA.

11. Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.

12. Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.

13. Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

14. Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

15. Departments of Neuroscience and Biomedical Engineering, Washington University, St. Louis, MO 63110, USA.

Abstract

A battery-free, soft implantable nerve cuff system provides wireless delivery of light and drugs to modulate nerve activity.

Funder

National Institute of Mental Health

National Institute on Drug Abuse

National Institute of General Medical Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Neurological Disorders and Stroke

National Institute of Biomedical Imaging and Bioengineering

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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