Platform for micro-invasive membrane-free biochemical sampling of brain interstitial fluid

Author:

Raman Ritu1ORCID,Rousseau Erin B.12ORCID,Wade Michael1,Tong Allison1ORCID,Cotler Max J.12ORCID,Kuang Jenevieve13,Lugo Alejandro Aponte1ORCID,Zhang Elizabeth14,Graybiel Ann M.45ORCID,White Forest M.136ORCID,Langer Robert17ORCID,Cima Michael J.18ORCID

Affiliation:

1. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

2. Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.

3. Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.

4. McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

5. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

6. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

7. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

8. Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Abstract

Micro-invasive platform performs label-free liquid biopsies of the brain, enabling in vivo tracking of proteins and peptides.

Funder

National Science Foundation

National Institutes of Health

Ford Foundation

American Association for the Advancement of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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