Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex

Author:

Chiner-Oms Á.1ORCID,Sánchez-Busó L.2ORCID,Corander J.234ORCID,Gagneux S.56ORCID,Harris S. R.7ORCID,Young D.8,González-Candelas F.19ORCID,Comas I.910ORCID

Affiliation:

1. Unidad Mixta “Infección y Salud Pública” FISABIO-CSISP/Universidad de Valencia, Instituto de Biología Integrativa de Sistemas (I2SysBio), Valencia, Spain.

2. Pathogen Genomics, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.

3. Department of Biostatistics, University of Oslo, 0317 Oslo, Norway.

4. Helsinki Institute of Information Technology (HIIT), Department of Mathematics and Statistics, University of Helsinki, 00014 Helsinki, Finland.

5. Swiss Tropical and Public Health Institute, Basel, Switzerland.

6. University of Basel, Basel, Switzerland.

7. Microbiotica, BioData Innovation Centre, Wellcome Genome Campus, Cambridge CB10 1DR, UK.

8. The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

9. CIBER en Epidemiología y Salud Pública, Valencia, Spain.

10. Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.

Abstract

Emergence and global success of tuberculosis involve core pathogenesis functions under selection in epidemiological settings.

Funder

H2020 European Research Council

Swiss National Science Foundation

Ministerio de Economía y Competitividad

Generalitat Valenciana

SystemsX.ch

Ministerio de Ciencia, Innovación y Universidades

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference63 articles.

1. B. J. Shapiro What microbial population genomics has taught us about speciation in Population Genomics M. Polz O. P. Rajora Eds. (Springer 2018).

2. Speciation trajectories in recombining bacterial species;Marttinen P.;PLOS Comput. Biol.,2017

3. Microbial speciation;Shapiro B. J.;Cold Spring Harb. Perspect. Biol.,2015

4. World Health Organization Global Tuberculosis Report 2017 (World Health Organization 2017); www.who.int/tb/publications/global_report/en/.

5. Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans

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