Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments

Author:

Liu Qingyun12ORCID,Wei Jianhao3ORCID,Li Yawei45ORCID,Wang Mei3ORCID,Su Jun3ORCID,Lu Yonghui3,López Mariana G.6ORCID,Qian Xueqin3ORCID,Zhu Zhaoqin3ORCID,Wang Haiying7ORCID,Gan Mingyun8,Jiang Qi19ORCID,Fu Yun-Xin10ORCID,Takiff Howard E.1112,Comas Iñaki613ORCID,Li Feng3ORCID,Lu Xuemei1415ORCID,Fortune Sarah M.21617ORCID,Gao Qian19ORCID

Affiliation:

1. Shanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Medical College and School of Basic Medical Sciences, Fudan University, Shanghai, China.

2. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

3. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

4. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.

5. University of Chinese Academy of Sciences, Beijing 100049, China.

6. Tuberculosis Genomic Unit, Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.

7. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

8. Molecular Medical Center, Children’s Hospital of Fudan University, Shanghai, China.

9. Shenzhen Center for Chronic Disease Control, Shenzhen, China.

10. Department of Biostatistics and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

11. Integrated Mycobacterial Pathogenomics Unit, Institut Pasteur, Paris, France.

12. Nanshan Center for Chronic Disease Control, Shenzhen, China.

13. CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.

14. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

15. CAS Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.

16. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

17. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Abstract

Massive single-colony sequencing revealed that mutation rates varied between different bacilli from the same patient.

Funder

National Institutes of Health

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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