Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex-Reference-Cited by-同舟云学术

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

Published:2022-01-07 Issue:1 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Hurdiss Daniel L.¹²^ORCID,El Kazzi Priscila³,Bauer Lisa¹^ORCID,Papageorgiou Nicolas³,Ferron François P.³^ORCID,Donselaar Tim¹,van Vliet Arno L.W.¹,Shamorkina Tatiana M.⁴^ORCID,Snijder Joost⁴^ORCID,Canard Bruno³^ORCID,Decroly Etienne³^ORCID,Brancale Andrea⁵^ORCID,Zeev-Ben-Mordehai Tzviya²^ORCID,Förster Friedrich²^ORCID,van Kuppeveld Frank J.M.¹^ORCID,Coutard Bruno⁶^ORCID

Affiliation:

1. Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, Netherlands.

2. Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.

3. Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.

4. Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, Netherlands.

5. School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.

6. Unité des Virus Émergents (UVE: Aix-Marseille Univ-IRD 190-Inserm 1207), Marseille, France.

Abstract

Researchers show how the antidepressant drug fluoxetine targets a viral protein and inhibits viral replication.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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