The Human Proteoform Project: Defining the human proteome

Author:

Smith Lloyd M.1ORCID,Agar Jeffrey N.2ORCID,Chamot-Rooke Julia3ORCID,Danis Paul O.4ORCID,Ge Ying5ORCID,Loo Joseph A.6ORCID,Paša-Tolić Ljiljana7ORCID,Tsybin Yury O.8ORCID,Kelleher Neil L.9ORCID,

Affiliation:

1. Department of Chemistry, University of Wisconsin, Madison, WI, USA.

2. Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.

3. Department of Structural Biology and Chemistry, Institut Pasteur, CNRS, Paris, France.

4. Consortium for Top-Down Proteomics, Cambridge, MA, USA.

5. Department of Cell and Regenerative Biology, Department of Chemistry, Human Proteomics Program, University of Wisconsin-Madison, Madison, WI, USA.

6. Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.

7. Pacific Northwest National Laboratory, Richland, WA, USA.

8. Spectroswiss, Lausanne, Switzerland.

9. Departments of Chemistry, Molecular Biosciences and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.

Abstract

An ambitious initiative is proposed to generate a definitive reference set of human proteoforms.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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