TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals-Reference-Cited by-同舟云学术

TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals

Published:2020-08-14 Issue:33 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Jin Hua¹²^ORCID,Xu Weijin¹^ORCID,Rahman Reazur¹^ORCID,Na Daxiang¹^ORCID,Fieldsend Allegra¹,Song Wei²,Liu Shaobo²,Li Chong²,Rosbash Michael¹^ORCID

Affiliation:

1. Department of Biology, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02453, USA.

2. Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, No. 5 South Zhongguancun Street, Beijing 100081, People's Republic of China.

Abstract

We used a relatively new method, HyperTRIBE, to identify in vivo RNA targets of the translation inhibitor 4E-BP.

Funder

National Institutes of Health

Howard Hughes Medical Institute

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. mTOR Signaling in Growth, Metabolism, and Disease

2. 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

3. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth

4. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP

5. mTOR, translation initiation and cancer

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