Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage-Reference-Cited by-同舟云学术

Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage

Published:2020-03-20 Issue:12 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Srinivasan Rajini¹^ORCID,Nady Nataliya¹^ORCID,Arora Neha¹^ORCID,Hsieh Laura J.²^ORCID,Swigut Tomek¹^ORCID,Narlikar Geeta J.²^ORCID,Wossidlo Mark¹³^ORCID,Wysocka Joanna¹⁴⁵⁶^ORCID

Affiliation:

1. Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

3. Department of Cell and Developmental Biology, Medical University of Vienna, 1090 Vienna, Austria.

4. Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

5. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

6. Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

A developmentally regulated mechanism, mediated by a zinc finger protein Zscan4, protects genome integrity in early embryos.

Funder

National Institutes of Health

Howard Hughes Medical Institute

Ludwig Institute for Cancer Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. Zygotic Genome Activation in Vertebrates

2. Zygotic Genome Activation During the Maternal-to-Zygotic Transition

3. Zygotic Genome Activation Triggers Chromosome Damage and Checkpoint Signaling in C. elegans Primordial Germ Cells

4. Zygotic Genome Activation Triggers the DNA Replication Checkpoint at the Midblastula Transition

5. Embryonic stem cell potency fluctuates with endogenous retrovirus activity

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