Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma

Author:

Li Jia1ORCID,Zhao Sibo23,Lee Minjung1,Yin Yue1,Li Jin1,Zhou Yubin4ORCID,Ballester Leomar Y.56,Esquenazi Yoshua6ORCID,Dashwood Roderick H.1ORCID,Davies Peter J. A.4,Parsons D. Williams2,Li Xiao-Nan27ORCID,Huang Yun1ORCID,Sun Deqiang189ORCID

Affiliation:

1. Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA.

2. Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA.

3. Department of Hematology and Oncology, Cook Children’s Medical Center, Fort Worth, TX 76104, USA.

4. Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA.

5. Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

6. Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

7. Program of Precision Medicine PDOX Modeling of Pediatric Cancers, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

8. Gomics Technology Corporation, 7707 Fannin Street, Suite 200, Houston, TX 77054, USA.

9. Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

Abstract

A reliable pipeline to identify DNA methylation signatures in CSF ctDNA could serve as potential biomarkers for MB patients.

Funder

National Institutes of Health

American Cancer Society

Welch Foundation

Cancer Prevention and Research Institute of Texas

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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