CLN7 is an organellar chloride channel regulating lysosomal function-Reference-Cited by-同舟云学术

CLN7 is an organellar chloride channel regulating lysosomal function

Published:2021-12-17 Issue:51 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wang Yayu¹^ORCID,Zeng Wenping¹^ORCID,Lin Bingqian¹^ORCID,Yao Yichuan²^ORCID,Li Canjun¹^ORCID,Hu Wenqi¹,Wu Haotian¹^ORCID,Huang Jiamin¹^ORCID,Zhang Mei²^ORCID,Xue Tian¹²^ORCID,Ren Dejian³,Qu Lili¹^ORCID,Cang Chunlei¹^ORCID

Affiliation:

1. Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Neurodegenerative Disorder Research Center, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China.

2. CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China.

3. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

The disease-associated protein CLN7 forms an organellar chloride channel and regulates lysosomal calcium signaling and function.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. The lysosome turns fifty

2. The cell biology of lysosomal storage disorders

3. Neuronal ceroid lipofuscinoses

4. Mutations in DNAJC5, Encoding Cysteine-String Protein Alpha, Cause Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis

5. Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis

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