Expedient synthesis of E -hydrazone esters and 1 H -indazole scaffolds through heterogeneous single-atom platinum catalysis

Author:

Liu Cuibo1ORCID,Chen Zhongxin1ORCID,Yan Huan1ORCID,Xi Shibo2ORCID,Yam Kah Meng3,Gao Jiajian4ORCID,Du Yonghua2,Li Jing1ORCID,Zhao Xiaoxu15ORCID,Xie Keyu6,Xu Haisen1ORCID,Li Xing1ORCID,Leng Kai1,Pennycook Stephen J.5ORCID,Liu Bin4,Zhang Chun3,Koh Ming Joo1ORCID,Loh Kian Ping1ORCID

Affiliation:

1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.

2. Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, Singapore 627833, Singapore.

3. Department of Physics, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.

4. School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.

5. Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore.

6. State Key Laboratory of Solidification Processing, Center for Nano Energy Materials, Northwestern Polytechnical University, Xi’an 710072, China.

Abstract

A heterogeneous Pt single-atom catalyst promotes E-selective synthesis of hydrazones en route to bioactive 1 H -indazoles.

Funder

National University of Singapore

National Research Foundation-Prime Minister’s office, Republic of Singapore

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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