Lowering apolipoprotein CIII protects against high-fat diet–induced metabolic derangements

Author:

Valladolid-Acebes Ismael1ORCID,Åvall Karin1ORCID,Recio-López Patricia1,Moruzzi Noah1ORCID,Bryzgalova Galyna1,Björnholm Marie2,Krook Anna3ORCID,Alonso Elena Fauste14ORCID,Ericsson Madelene5ORCID,Landfors Fredrik5ORCID,Nilsson Stefan K.5,Berggren Per-Olof16789,Juntti-Berggren Lisa1ORCID

Affiliation:

1. The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, SE-171 76 Stockholm, Sweden.

2. Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

3. Department of Physiology and Pharmacology, C3, Integrative Physiology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

4. Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Montepríncipe, Boadilla del Monte, Madrid, Spain.

5. Department of Medical Biosciences, Unit of Physiological Chemistry 6M, Umeå University, SE-901 85 Umeå, Sweden.

6. Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.

7. Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

8. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 637553, Singapore.

9. Center for Diabetes and Metabolism Research, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China.

Abstract

Diet-induced obesity, fatty liver, and type 2 diabetes are prevented by lowering apoCIII.

Funder

AstraZeneca

Novo Nordisk Fonden

Svenska Diabetesstiftelsen

The swedish Research Council

Strategic Research Program in Diabetes at Karolinska Institutet

Swedish Diabetes Association

Skandia Insurance Company LtD

Diabetes Wellness Foundation

The Family Knut and Alice Wallenberg Foundation

The Stichting af Jochnick Foundation

The Family Erling-Persson Foundation

The Bert von Kantzow Foundation

Swedish Association for Diabetology

The ERC-EYLETS

Funds of Karolinska Institutet

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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