The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain-Reference-Cited by-同舟云学术

The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain

Author:

Hajal Cynthia¹^ORCID,Shin Yoojin¹,Li Leanne²^ORCID,Serrano Jean Carlos¹^ORCID,Jacks Tyler²³⁴^ORCID,Kamm Roger D.¹⁵^ORCID

Affiliation:

1. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Astrocyte-secreted CCL2 promotes cancer cell extravasation at the brain via chemotaxis and chemokinesis.

Funder

National Science Foundation

Howard Hughes Medical Institute

National Cancer Institute

Cure Alzheimer’s Fund

Hope Funds for Cancer Research

Ludwig Center for Molecular Oncology

Ludwig Center at Harvard

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference70 articles.

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