Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

Author:

Chu Hin123ORCID,Shuai Huiping12ORCID,Hou Yuxin2ORCID,Zhang Xi2,Wen Lei2ORCID,Huang Xiner2,Hu Bingjie2,Yang Dong2ORCID,Wang Yixin2,Yoon Chaemin2ORCID,Wong Bosco Ho-Yin2ORCID,Li Cun2ORCID,Zhao Xiaoyu2ORCID,Poon Vincent Kwok-Man2ORCID,Cai Jian-Piao2ORCID,Wong Kenneth Kak-Yuen4,Yeung Man-Lung123ORCID,Zhou Jie123ORCID,Au-Yeung Rex Kwok-Him5ORCID,Yuan Shuofeng123ORCID,Jin Dong-Yan6ORCID,Kok Kin-Hang12ORCID,Perlman Stanley7ORCID,Chan Jasper Fuk-Woo12389ORCID,Yuen Kwok-Yung12389ORCID

Affiliation:

1. State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

2. Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

3. Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

4. Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

5. Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

6. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

7. Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.

8. Department of Clinical Microbiology and Infection Control, The University of Hong Kong–Shenzhen Hospital, Shenzhen, Guangdong Province, China.

9. Hainan Medical University–The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

Abstract

Infection of highly pathogenic coronaviruses triggers apoptosis that can be targeted to reduce disease severity.

Funder

Health and Medical Research Fund

GRF

HMRF

HKU

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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