Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

Author:

Luginina Aleksandra1ORCID,Gusach Anastasiia1ORCID,Marin Egor1ORCID,Mishin Alexey1ORCID,Brouillette Rebecca2ORCID,Popov Petr1,Shiriaeva Anna3,Besserer-Offroy Élie2ORCID,Longpré Jean-Michel2ORCID,Lyapina Elizaveta1ORCID,Ishchenko Andrii3,Patel Nilkanth3ORCID,Polovinkin Vitaly456ORCID,Safronova Nadezhda1ORCID,Bogorodskiy Andrey1,Edelweiss Evelina5,Hu Hao78ORCID,Weierstall Uwe78ORCID,Liu Wei89,Batyuk Alexander10ORCID,Gordeliy Valentin1451112,Han Gye Won3ORCID,Sarret Philippe2ORCID,Katritch Vsevolod3ORCID,Borshchevskiy Valentin1411ORCID,Cherezov Vadim13ORCID

Affiliation:

1. Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.

2. Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.

3. Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.

4. Institute of Complex Systems, ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.

5. Institut de Biologie Structurale J.-P. Ebel, Université Grenoble Alpes-CEA-CNRS, Grenoble 38000, France.

6. ELI Beamlines, Institute of Physics, Czech Academy of Sciences, 18221 Prague, Czech Republic.

7. Department of Physics, Arizona State University, Tempe, AZ 85287, USA.

8. Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.

9. School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.

10. Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.

11. Juelich Center for Structural Biology, Research Center Juelich, Juelich, Germany.

12. Institute of Crystallography, RWTH Aachen University, Aachen, Germany.

Abstract

Two distinct antagonist-bound structures of CysLT 1 R reveal unique ligand-binding modes and signaling mechanisms.

Funder

National Science Foundation

National Institute on Drug Abuse

National Institute of General Medical Sciences

Canadian Institutes of Health Research

Russian Foundation for Basic Research

Russian Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Cited by 78 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3