Wearable microneedle-based electrochemical aptamer biosensing for precision dosing of drugs with narrow therapeutic windows-Reference-Cited by-同舟云学术

Wearable microneedle-based electrochemical aptamer biosensing for precision dosing of drugs with narrow therapeutic windows

Published:2022-09-23 Issue:38 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Lin Shuyu¹²^ORCID,Cheng Xuanbing¹²³^ORCID,Zhu Jialun¹²³,Wang Bo¹²^ORCID,Jelinek David⁴⁵,Zhao Yichao¹²³^ORCID,Wu Tsung-Yu¹²³^ORCID,Horrillo Abraham⁴^ORCID,Tan Jiawei¹²³^ORCID,Yeung Justin¹³,Yan Wenzhong⁶^ORCID,Forman Sarah¹⁴,Coller Hilary A.⁴⁷⁸^ORCID,Milla Carlos⁹^ORCID,Emaminejad Sam¹²¹⁰^ORCID

Affiliation:

1. Interconnected and Integrated Bioelectronics Lab (I2BL), University of California, Los Angeles, Los Angeles, CA, USA.

2. Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

3. Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

4. Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.

5. Weintraub Center for Reconstructive Biotechnology, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA.

6. Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA, USA.

7. Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

8. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.

9. The Stanford Cystic Fibrosis Center, Center for Excellence in Pulmonary Biology, Stanford School of Medicine, Stanford, CA, USA.

10. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.

Abstract

Therapeutic drug monitoring is essential for dosing pharmaceuticals with narrow therapeutic windows. Nevertheless, standard methods are imprecise and involve invasive/resource-intensive procedures with long turnaround times. Overcoming these limitations, we present a microneedle-based electrochemical aptamer biosensing patch (μNEAB-patch) that minimally invasively probes the interstitial fluid (ISF) and renders correlated, continuous, and real-time measurements of the circulating drugs’ pharmacokinetics. The μNEAB-patch is created following an introduced low-cost fabrication scheme, which transforms a shortened clinical-grade needle into a high-quality gold nanoparticle-based substrate for robust aptamer immobilization and efficient electrochemical signal retrieval. This enables the reliable in vivo detection of a wide library of ISF analytes—especially those with nonexistent natural recognition elements. Accordingly, we developed μNEABs targeting various drugs, including antibiotics with narrow therapeutic windows (tobramycin and vancomycin). Through in vivo animal studies, we demonstrated the strong correlation between the ISF/circulating drug levels and the device’s potential clinical use for timely prediction of total drug exposure.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference65 articles.

1. On-Site Therapeutic Drug Monitoring

2. ‘Cost–benefit analysis comparing trough, two-level AUC, and Bayesian AUC dosing for vancomycin’: authors' reply

3. Comparative Nephrotoxicity of Gentamicin and Tobramycin in Rats

4. Therapeutic Drug Monitoring of Antibiotics in Critically Ill Patients: Current Practice and Future Perspectives With a Focus on Clinical Outcome

5. Noninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics

Cited by 54 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The combination of DNA nanostructures and materials for highly sensitive electrochemical detection;Bioelectrochemistry;2024-06

2. The role of ligands on synthesis, functional control, and biomedical applications of near-infrared light-responsive metal-based nanoparticles;Coordination Chemistry Reviews;2024-03

3. Rational Approach to Optimizing Conformation-Switching Aptamers for Biosensing Applications;ACS Sensors;2024-01-25

4. Surface-Enhanced Raman Spectroscopy for Quantitative Analysis of Anesthetic Agents: Toward Personalized Drug Monitoring in Anesthesia;ACS Materials Letters;2024-01-24

5. Real-Time Measurement of Antiglaucoma Drugs in Porcine Eyes Using Boron-Doped Diamond Microelectrodes;ACS Sensors;2024-01-20