Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor-Reference-Cited by-同舟云学术

Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor

Published:2020-07-17 Issue:29 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Köhler C.¹^ORCID,Carlström G.²^ORCID,Gunnarsson A.³,Weininger U.⁴^ORCID,Tångefjord S.¹³^ORCID,Ullah V.¹,Lepistö M.¹,Karlsson U.³,Papavoine T.¹^ORCID,Edman K.³^ORCID,Akke M.⁴^ORCID

Affiliation:

1. Respiratory, Inflammation and Autoimmunity, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

2. Centre for Analysis and Synthesis, Department of Chemistry, Lund University, P.O. Box 124, 221 00 Lund, Sweden.

3. Discovery Sciences, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

4. Division of Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, P. O. Box 124, 221 00 Lund, Sweden.

Abstract

Allosteric communication pathways in the glucocorticoid receptor ligand-binding domain respond to ligand structure.

Funder

AstraZeneca

The swedish Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. Glucocorticoid receptor control of transcription: precision and plasticity via allostery

2. Specificity and sensitivity of glucocorticoid signaling in health and disease