Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display-Reference-Cited by-同舟云学术

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

Published:2019-09-06 Issue:9 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Vragniau Charles¹^ORCID,Bufton Joshua C.²^ORCID,Garzoni Frédéric³,Stermann Emilie¹,Rabi Fruzsina²,Terrat Céline⁴^ORCID,Guidetti Mélanie⁵^ORCID,Josserand Véronique⁵^ORCID,Williams Matt⁶^ORCID,Woods Christopher J.⁶,Viedma Gerardo⁷^ORCID,Bates Phil⁷^ORCID,Verrier Bernard⁴,Chaperot Laurence⁸^ORCID,Schaffitzel Christiane²^ORCID,Berger Imre²⁹^ORCID,Fender Pascal¹^ORCID

Affiliation:

1. Institut de Biologie Structurale (IBS), Université Grenoble Alpes, CNRS, CEA, 71 Avenue des Martyrs, 38042 Grenoble, France.

2. Bristol Research Centre for Synthetic Biology BrisSynBio, School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK.

3. Imophoron Ltd., Unit DX, St. Philips Central, Albert Road, Bristol BS2 OXJ, UK.

4. Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique (LBTI), UMR 5305, Université Lyon 1, CNRS, Institut de Biologie et Chimie des Protéines (IBCP), Lyon, France.

5. Cancer Target and Experimental Therapeutics, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38700 Grenoble, France.

6. Advanced Computing Research Centre, University of Bristol, 31 Great George Street, Bristol BS1 5QD, UK.

7. Oracle Cloud Development Centre, Tower Wharf, Cheese Lane, Bristol BS2 2JJ, UK.

8. Immunobiology and Immunotherapy in Chronic Diseases, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Etablissement Français du Sang-Rhone-Alpes, 38700 Grenoble, France.

9. Max Planck-Bristol Centre for Minimal Biology, Cantock’s Close, Bristol BS8 1TS, UK.

Abstract

ADDomer is a synthetic, self-assembling, virus-like particle platform that enables highly efficient vaccination.

Funder

Wellcome Trust

Oracle

Wellcome

European Commission

BBSRC

EPSRC

Agence Nationale de la Recherche

Publisher