M-CSF, IL-6, and TGF-β promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery

Author:

Li Zhiqi12ORCID,Xiao Jun3ORCID,Xu Xiaoyan34ORCID,Li Weiyun35ORCID,Zhong Ruiyue3ORCID,Qi Linlin67ORCID,Chen Jiehui3,Cui Guizhong3ORCID,Wang Shuang3ORCID,Zheng Yuxiao3ORCID,Qiu Ying3ORCID,Li Sheng3ORCID,Zhou Xin38ORCID,Lu Yao3ORCID,Lyu Jiaying9,Zhou Bin3ORCID,Zhou Jiawei10ORCID,Jing Naihe3,Wei Bin678ORCID,Hu Jin11112ORCID,Wang Hongyan213ORCID

Affiliation:

1. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.

2. Neurosurgical Institute, Fudan University, Shanghai 200040 China.

3. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

4. Experimental Immunology Branch, National Cancer Institute, U.S. National Institutes of Health, Bethesda, MD, USA.

5. School of Life Sciences, Xiamen University, Xiamen, Fujian, China.

6. School of Life Sciences, Shanghai University, Shanghai 200444, China.

7. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

8. Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China.

9. Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China.

10. Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China.

11. Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China.

12. Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China.

13. School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.

Abstract

The combination use of TGF-β, M-CSF, and IL-6 represents a promising therapy to repair traumatic brain injury.

Funder

National Natural Science Foundation of China

the Ministry of Science and Technology of China

The Strategic Priority Research Program of the Chinese Academy of Sciences

the Hundred Talents Program of the Chinese Academy of Sciences

the State Key Laboratory of Cell Biology, SIBCB, CAS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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