ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment

Author:

Liu Jiye1ORCID,Hideshima Teru1ORCID,Xing Lijie12,Wang Su3,Zhou Wenrong4,Samur Mehmet K.15ORCID,Sewastianik Tomasz67ORCID,Ogiya Daisuke1,An Gang8,Gao Shaobing9ORCID,Yang Li10,Ji Tong11,Bianchi Giada12,Wen Kenneth1,Tai Yu-Tzu1ORCID,Munshi Nikhil1,Richardson Paul1ORCID,Carrasco Ruben613,Cang Yong14ORCID,Anderson Kenneth C.1ORCID

Affiliation:

1. Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

2. Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.

3. Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

4. Oncology and Immunology Unit, Research Service Division, WuXi AppTec (Shanghai) Co., Ltd., Shanghai 200131, China.

5. Department of Biostatistics and Computational Biology, Harvard T.H. Chan School of Public Health, Boston, 02115 MA, USA.

6. Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

7. Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw 02776, Poland.

8. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China.

9. The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China.

10. Multiple Myeloma Treatment Center and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

11. Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020, China.

12. Division of Hematology, Department of Internal Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

13. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

14. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Abstract

Blocking of MEK-ERK pathway overcomes myeloma cells resistance to immunomodulatory drugs in the bone marrow microenvironment.

Funder

National Institutes of Health

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

National Natural Science Foundation of China

Riney Family Myeloma Initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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