Biomaterials with structural hierarchy and controlled 3D nanotopography guide endogenous bone regeneration

Author:

Chen Shixuan1ORCID,Wang Hongjun1ORCID,Mainardi Valerio Luca23ORCID,Talò Giuseppe4ORCID,McCarthy Alec1ORCID,John Johnson V.1ORCID,Teusink Matthew J.5ORCID,Hong Liu6ORCID,Xie Jingwei17ORCID

Affiliation:

1. Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA.

2. Regenerative Medicine Technologies Lab, Ente Ospedaliero Cantonale (EOC), via Tesserete 46, 6900, Lugano, Switzerland.

3. Laboratory of Biological Structures Mechanics (LaBS), Department of Chemistry, Material and Chemical Engineering “Giulio Natta”, Politecnico di Milano, 20133, Milan, Italy.

4. IRCCS Istituto Ortopedico Galeazzi, Cell and Tissue Engineering Laboratory, via Galeazzi, 4, 20161, Milan, Italy.

5. Department of Orthaepedic Surgery and Rehabilitation, University of Nebraska Medical Center, Omaha, NE 68198, USA.

6. Iowa Institute for Oral Health Research, The University of Iowa, Iowa City, IA 52242, USA.

7. Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.

Abstract

Biomaterials without incorporating therapeutic agents and living cells effectively repair critical-sized rat cranial bone defects.

Funder

National Institutes of Health

National Institute of General Medical Sciences

National Institute of Dental and Craniofacial Research

Nebraska State

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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