Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area-Reference-Cited by-同舟云学术

Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

Published:2019-07-05 Issue:7 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zhao Runchen¹²^ORCID,Afthinos Alexandros¹²^ORCID,Zhu Tian¹²^ORCID,Mistriotis Panagiotis¹²^ORCID,Li Yizeng²³^ORCID,Serra Selma A.⁴^ORCID,Zhang Yuqi¹²^ORCID,Yankaskas Christopher L.¹²^ORCID,He Shuyu¹^ORCID,Valverde Miguel A.⁴^ORCID,Sun Sean X.¹²³⁵⁶^ORCID,Konstantopoulos Konstantinos¹²⁵⁶⁷^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

2. Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

3. Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

4. Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

5. Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, MD 21218, USA.

6. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

7. Department of Oncology, Johns Hopkins University, Baltimore, MD 21205, USA.

Abstract

TRPM7 senses hydraulic pressure and modulates cortical actomyosin to guide migrating cells towards the path of lower resistance.

Funder

National Institutes of Health

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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