Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing-Reference-Cited by-同舟云学术

Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing

Published:2020-09-04 Issue:36 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zhao Hongliang¹^ORCID,Brooks Seth A.¹,Eszterhas Susan¹,Heim Spencer¹,Li Liang²^ORCID,Xiong Yan Q.²,Fang Yongliang¹³,Kirsch Jack R.¹^ORCID,Verma Deeptak⁴^ORCID,Bailey-Kellogg Chris³⁴⁵^ORCID,Griswold Karl E.¹³⁵^ORCID

Affiliation:

1. Thayer School of Engineering, Dartmouth, Hanover, NH 03755, USA.

2. Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

3. Lyticon LLC, Lebanon, NH 03766, USA.

4. Department of Computer Science, Dartmouth, Hanover, NH 03755, USA.

5. Stealth Biologics LLC, Lebanon, NH 03766, USA.

Abstract

A deimmunized lysostaphin biotherapy evades detrimental antidrug immune reactions and has improved efficacy for MRSA infections.

Funder

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

New Hampshire Innovation Research Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference54 articles.

1. Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

2. Antibiotic Resistance Threats in the United States 2013 (2013); http://cdc.gov/drugresistance/threat-report-2013/.

3. Waves of resistance: Staphylococcus aureus in the antibiotic era

4. Treatment of Staphylococcus aureus Infections;David M. Z.;Curr. Top. Microbiol. Immunol.,2017

5. Development of Phage Lysins as Novel Therapeutics: A Historical Perspective

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