Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality

Author:

Brunet-Ratnasingham Elsa12ORCID,Anand Sai Priya13,Gantner Pierre12,Dyachenko Alina1ORCID,Moquin-Beaudry Gaël14ORCID,Brassard Nathalie1,Beaudoin-Bussières Guillaume12,Pagliuzza Amélie1ORCID,Gasser Romain1ORCID,Benlarbi Mehdi1ORCID,Point Floriane1ORCID,Prévost Jérémie12,Laumaea Annemarie1,Niessl Julia12ORCID,Nayrac Manon12,Sannier Gérémy12ORCID,Orban Catherine25,Messier-Peet Marc15,Butler-Laporte Guillaume67ORCID,Morrison David R.6ORCID,Zhou Sirui67ORCID,Nakanishi Tomoko68910ORCID,Boutin Marianne12,Descôteaux-Dinelle Jade12,Gendron-Lepage Gabrielle1ORCID,Goyette Guillaume1ORCID,Bourassa Catherine1ORCID,Medjahed Halima1,Laurent Laetitia6,Rébillard Rose-Marie14ORCID,Richard Jonathan12,Dubé Mathieu1,Fromentin Rémi1ORCID,Arbour Nathalie14ORCID,Prat Alexandre14ORCID,Larochelle Catherine14ORCID,Durand Madeleine15ORCID,Richards J. Brent67811,Chassé Michaël15ORCID,Tétreault Martine14,Chomont Nicolas12ORCID,Finzi Andrés123ORCID,Kaufmann Daniel E.12512ORCID

Affiliation:

1. Research Centre of the Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, QC, Canada.

2. Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada.

3. Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.

4. Department of Neuroscience, Université de Montréal, Montréal, QC, Canada.

5. Centre hospitalier de l’Université de Montréal (CHUM), Montréal, QC, Canada.

6. Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, QC, Canada.

7. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.

8. Department of Human Genetics, McGill University, Montreal, QC, Canada.

9. Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

10. Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, 102-0083 Tokyo, Japan.

11. Department of Twin Research, King’s College London, London, UK.

12. Département de Médecine, Université de Montréal, Montréal, QC, Canada.

Abstract

Statistical models of plasma immunovirological features validate SARS-CoV-2 vRNA as an early predictor of COVID-19 mortality.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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