Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children

Author:

Prentice Andrew M.1ORCID,Bah Amat1,Jallow Momodou W.1,Jallow Amadou T.1ORCID,Sanyang Saikou1,Sise Ebrima A.1,Ceesay Kabiru1,Danso Ebrima1,Armitage Andrew E.2ORCID,Pasricha Sant-Rayn3ORCID,Drakesmith Hal2,Wathuo Miriam1ORCID,Kessler Noah14ORCID,Cerami Carla1ORCID,Wegmüller Rita156ORCID

Affiliation:

1. MRC Unit The Gambia at LSHTM, Atlantic Road, Fajara, The Gambia.

2. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

3. Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Melbourne, Parkville, Victoria 3052, Australia.

4. Department of Genetics, University of Cambridge, Cambridge, UK.

5. GroundWork, 7306 Fläsch, Switzerland.

6. Human Nutrition Laboratory, Institute of Food, Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.

Abstract

Inflammation from respiratory infections contributes to iron deficiency anemia in children by blocking iron absorption.

Funder

Bill and Melinda Gates Foundation

Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. World Health Organization The Global Prevalence of Anaemia in 2011 (World Health Organization 2015).

2. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

3. Point-of-use fortification of foods with micronutrient powders containing iron in children of preschool and school-age;De-Regil L. M.;Cochrane Database Syst. Rev.,2017

4. World Health Organization WHO Guideline: Use of Multiple Micronutrient Powders for Point-of-Use Fortication of Foods Consumed by Infants and Young Children Aged 6–23 Months and Children Aged 2–12 Years (World Health Organization 2016).

5. Effect of daily iron supplementation on health in children aged 4-23 months: A systematic review and meta-analysis of randomised controlled trials;Pasricha S. R.;Lancet Glob. Health,2013

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