A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues-Reference-Cited by-同舟云学术

A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Published:2021-01-29 Issue:5 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Nims Robert J.¹²³^ORCID,Pferdehirt Lara¹²³⁴^ORCID,Ho Noelani B.⁵⁶^ORCID,Savadipour Alireza¹²³⁷^ORCID,Lorentz Jeremiah¹²³⁴,Sohi Sima⁴^ORCID,Kassab Jordan⁴^ORCID,Ross Alison K.¹²³⁴^ORCID,O’Conor Christopher J.⁸,Liedtke Wolfgang B.⁹^ORCID,Zhang Bo³^ORCID,McNulty Amy L.⁵¹⁰^ORCID,Guilak Farshid¹²³⁴⁷^ORCID

Affiliation:

1. Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Shriners Hospitals for Children—Saint Louis, St. Louis, MO 63110, USA.

3. Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

4. Department of Biomedical Engineering, Washington University, St. Louis, MO 63105, USA.

5. Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

6. Department of Biology, Duke University, Durham, NC 27708, USA.

7. Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO 63105, USA.

8. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

9. Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.

10. Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

Abstract

A mechanogenetic system was developed using a synthetic gene circuit to produce biologic drugs in response to mechanical loading.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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