Biodegradable silicon nanoneedles for ocular drug delivery-Reference-Cited by-同舟云学术

Biodegradable silicon nanoneedles for ocular drug delivery

Published:2022-04 Issue:13 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Park Woohyun¹^ORCID,Nguyen Van Phuc²^ORCID,Jeon Yale³,Kim Bongjoong⁴⁵^ORCID,Li Yanxiu²,Yi Jonghun³,Kim Hyungjun⁴⁶^ORCID,Leem Jung Woo⁴^ORCID,Kim Young L.⁴^ORCID,Kim Dong Rip³^ORCID,Paulus Yannis M.²⁷^ORCID,Lee Chi Hwan¹⁴⁸⁹^ORCID

Affiliation:

1. School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.

2. Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.

3. School of Mechanical Engineering, Hanyang University, Seoul 04763, Republic of Korea.

4. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

5. Department of Mechanical and System Design Engineering, Hongik University, Seoul 04066, Republic of Korea.

6. Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi, Gyeongbuk 39177, Republic of Korea.

7. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.

8. Department of Materials Engineering, Purdue University, West Lafayette, IN 47907, USA.

9. Birck Nanotechnology Center, Purdue University, West Lafayette, IN 47907, USA.

Abstract

Ocular drug delivery remains a grand challenge due to the complex structure of the eye. Here, we introduce a unique platform of ocular drug delivery through the integration of silicon nanoneedles with a tear-soluble contact lens. The silicon nanoneedles can penetrate into the cornea in a minimally invasive manner and then undergo gradual degradation over the course of months, enabling painless and long-term sustained delivery of ocular drugs. The tear-soluble contact lens can fit a variety of corneal sizes and then quickly dissolve in tear fluid within a minute, enabling an initial burst release of anti-inflammatory drugs. We demonstrated the utility of this platform in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a notable side effect over current standard therapies. This platform could also be useful in treating other chronic ocular diseases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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