A distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1

Author:

Jin Huaibing123ORCID,Du Zhiqiang1ORCID,Zhang Yanjing1ORCID,Antal Judit4,Xia Zongliang1,Wang Yan1ORCID,Gao Yang1ORCID,Zhao Xiaoge12,Han Xinyun1,Cheng Yanjun1,Shen Qianhua1,Zhang Kunpu13,Elder Robert E.4ORCID,Benko Zsigmond4,Fenyvuesvolgyi Csaba4,Li Ge5,Rebello Dionne5ORCID,Li Jing6,Bao Shilai6,Zhao Richard Y.457ORCID,Wang Daowen123ORCID

Affiliation:

1. State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

2. University of Chinese Academy of Sciences, Beijing 100049, China.

3. College of Agronomy and State Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou 450002, China.

4. Children’s Memorial Institute for Education and Research, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA.

5. Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

6. State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

7. Department of Microbiology and Immunology, Institute of Human Virology, and Institute of Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Abstract

A distinct class of mitosis regulators, conserved between plant and animal viruses, play active roles in viral pathogenesis.

Funder

Ministry of Science and Technology of China

University of Maryland Medical Center

Chicago Children’s Memorial Institute for Education and Research, Northwestern University Feinberg School of Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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