Multiple lipid binding sites determine the affinity of PH domains for phosphoinositide-containing membranes-Reference-Cited by-同舟云学术

Multiple lipid binding sites determine the affinity of PH domains for phosphoinositide-containing membranes

Published:2020-02-21 Issue:8 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yamamoto Eiji¹^ORCID,Domański Jan²³,Naughton Fiona B.²⁴^ORCID,Best Robert B.³^ORCID,Kalli Antreas C.²⁵^ORCID,Stansfeld Phillip J.²^ORCID,Sansom Mark S. P.²^ORCID

Affiliation:

1. Department of System Design Engineering, Keio University, Yokohama, Kanagawa 223-8522, Japan.

2. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

3. Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA.

4. Department of Physics, Arizona State University, Tempe, AZ 85287-1504, USA.

5. Leeds Institute of Cardiovascular and Metabolic Medicine and Astbury Center for Structural Molecular Biology, University of Leeds, Leeds, UK.

Abstract

Molecular simulations reveal that multiple lipid interactions are needed for high-affinity binding of protein domains to membranes.

Funder

National Institutes of Health

National Institute of Diabetes and Digestive and Kidney Diseases

Wellcome

JSPS KAKENHI

BBSRC

EPSRC

MRC