Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors

Author:

Talavera Ariel12ORCID,Hendrix Jelle34ORCID,Versées Wim12,Jurėnas Dukas5ORCID,Van Nerom Katleen5,Vandenberk Niels3ORCID,Singh Ranjan Kumar12ORCID,Konijnenberg Albert126,De Gieter Steven12,Castro-Roa Daniel7,Barth Anders8ORCID,De Greve Henri12,Sobott Frank6910ORCID,Hofkens Johan311ORCID,Zenkin Nikolay7ORCID,Loris Remy12ORCID,Garcia-Pino Abel5ORCID

Affiliation:

1. Structural Biology Brussels, Department of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.

2. Center for Structural Biology, VIB, Flanders, Belgium.

3. Molecular Imaging and Photonics, University of Leuven, B-3001 Leuven, Belgium.

4. Biomedical Research Institute, Hasselt University, B-3590 Hasselt, Belgium.

5. Cellular and Molecular Microbiology, Department of Molecular Biology, Université Libre de Bruxelles, Brussels, Belgium.

6. Biomolecular and Analytical Mass Spectrometry Group, Department of Chemistry, University of Antwerp, Antwerp, Belgium.

7. Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK.

8. Fluorescence Applications in Biology Laboratory, Department of Chemistry and Pharmacy, Ludwig-Maximilians-Universität München, Munich, Germany.

9. School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.

10. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

11. Nano-Science Center, Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark.

Abstract

Phosphorylation-induced conformational trap is an essential mechanism for phosphoregulation of bacterial metabolism.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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