GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice-Reference-Cited by-同舟云学术

GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice

Published:2021-10-15 Issue:42 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Beckerman Margarita¹²^ORCID,Harel Chava²³,Michael Inbal¹,Klip Amira⁴^ORCID,Bilan Philip J.⁴^ORCID,Gallagher Emily J.⁵^ORCID,LeRoith Derek⁵,Lewis Eli C.⁶,Karnieli Eddy²³,Levenberg Shulamit¹²^ORCID

Affiliation:

1. Faculty of Biomedical Engineering, Technion—Israel Institute of Technology, Haifa, Israel.

2. Rina and Avner Schneur Center of Diabetes Research, Technion—Israel Institute of Technology, Haifa, Israel.

3. Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa, Israel.

4. Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

5. Division of Endocrinology, Diabetes and Bone Diseases, Samuel Bronfman Department of Medicine, Ichan School of Medicine at Mount Sinai, New York, NY 10029, USA.

6. Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Abstract

GLUT4-overexpressing engineered muscle constructs improve mice diabetic state and show a potential as a therapeutic tool.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference71 articles.

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4. Muscle–Organ Crosstalk: The Emerging Roles of Myokines

5. Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

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