Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma

Author:

Ogunnaike Edikan A.123ORCID,Valdivia Alain4ORCID,Yazdimamaghani Mostafa13,Leon Ernesto1ORCID,Nandi Seema2,Hudson Hannah1ORCID,Du Hongwei1ORCID,Khagi Simon15,Gu Zhen67ORCID,Savoldo Barbara18,Ligler Frances S.23ORCID,Hingtgen Shawn4ORCID,Dotti Gianpietro19ORCID

Affiliation:

1. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

2. Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina at Chapel Hill, Raleigh, NC 27695, USA.

3. Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

4. Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

5. Department of Medicine, Division of Medical Oncology, University of North Carolina, Chapel Hill, NC 27599, USA.

6. Department of Bioengineering, University of California, Los Angeles, CA 90095, USA.

7. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.

8. Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27514, USA.

9. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

Abstract

In situ fibrin gel promotes the survival and the biodistribution of CAR-T cells, eliminating residual GBM cells after surgery.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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