A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression

Author:

Agarwal Ekta12ORCID,Goldman Aaron R.3ORCID,Tang Hsin-Yao3ORCID,Kossenkov Andrew V.3ORCID,Ghosh Jagadish C.12,Languino Lucia R.4,Vaira Valentina56ORCID,Speicher David W.13,Altieri Dario C.12ORCID

Affiliation:

1. Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA 19104, USA.

2. Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.

3. Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA 19104, USA.

4. Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

5. Division of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.

6. Department of Pathophysiology and Transplantation, University of Milan, Milan 20122, Italy.

Abstract

A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression.

Funder

National Institutes of Health

R50

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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